MCB/LISCB Research-in-Progress Seminars 2022-23

Meetings will take place Fridays at 12:30pm either online or in the Frank and Katherine May Lecture Theatre. The series is organized by Tennie Videler and Thomas Schalch.

Date
Speaker
Affiliation
Fri, 07. Oct. 2022
12:30, HWB FKMLT
Oksana Gonchar
Schwabe lab
Studying functions of histone deacetylase complexes
Joshua Graham
Panne lab
Structural and molecular insights into Cohesin and its release factor WAPL
Fri, 14. Oct. 2022
00:30, HWB FKMLT
Richard J. Hopkinson
Hopkinson lab
Defining the enigmatic biology of aldehydes
Fri, 04. Nov. 2022
12:30, HWB FKMLT
Carlos Bueno Alejo
Hudson lab
Fluorous effect in single molecule microscopy
Panos Patsis
Schalch lab
Dissecting the regulatory mechanisms governing the histone 3 lysine 9 methyltransferase Clr4
Fri, 11. Nov. 2022
12:30, HWB FKMLT
Robert Liddington
Moody lab
PurC as a potential target for novel therapeutics to treat multi-drug resistant tuberculosis.
Fri, 18. Nov. 2022
12:30, HWB FKMLT
Richard Cowan
Carr lab
Predicting Antibody:Target interfaces and novel protein:protein interactions with Alphafold
Beatriz Romartinez
Schwabe lab
Structural insight into the cholesterol transport and lipid metabolism
Fri, 25. Nov. 2022
12:30, HWB FKMLT
David English
Cowley lab
‘Investigating the role of HDAC1 containing corepressor complexes’
Fri, 02. Dec. 2022
12:30, HWB FKMLT
Tajith Shaik
Panne lab
Structural investigation of cohesin cycle
Siyu Wang
Schwabe lab
Investigations into the MIER1 co-repressor complex
Fri, 09. Dec. 2022
12:30, HWB FKMLT
TBD
Dominguez lab
Fri, 13. Jan. 2023
12:30, HWB FKMLT
TBD
Eperon lab
Fri, 20. Jan. 2023
12:30, HWB FKMLT
TBD
Doveston lab
Robert Turnbull
Schwabe lab
Fri, 27. Jan. 2023
12:30, HWB FKMLT
TBD
Gooptu lab
Fri, 03. Feb. 2023
12:30, HWB FKMLT
TBD
Macip lab
TBD
Hodgkinson lab
Fri, 10. Feb. 2023
12:30, HWB FKMLT
Louise Fairall
Schwabe lab
Fri, 17. Feb. 2023
12:30, HWB FKMLT
TBD
Hopkinson lab
TBD
Panne lab
Fri, 03. Mar. 2023
12:30, HWB FKMLT
TBD
Hudson lab
TBD
Carr lab
Fri, 10. Mar. 2023
12:30, HWB FKMLT
Ed Brown
Schwabe lab
Fri, 17. Mar. 2023
12:30, HWB FKMLT
TBD
Fox lab
TBD
Suntharalingam lab
Fri, 24. Mar. 2023
12:30, HWB FKMLT
TBD
Gooptu lab
Fri, 21. Apr. 2023
11:30, HWB FKMLT
TBD
Vuister lab
Liam Regan
Schwabe lab
Fri, 28. Apr. 2023
12:30, HWB FKMLT
TBD
Panne lab
Fri, 05. May. 2023
11:30, HWB FKMLT
India-May Baker
Cowley lab
Rufus Frew
Ash lab
Fri, 12. May. 2023
12:30, HWB FKMLT
Yubin Huang
Schwabe lab
Fri, 19. May. 2023
11:30, HWB FKMLT
Samuel Foster
Moody lab
TBD
Vuister lab
Fri, 09. Jun. 2023
12:30, HWB FKMLT
TBD
Dominguez lab
TBD
Gooptu lab
Fri, 16. Jun. 2023
11:30, HWB FKMLT
Kristupas Sirvydus
Schwabe lab
Fri, 30. Jun. 2023
11:30, HWB FKMLT
TBD
Macip lab
Fri, 07. Jul. 2023
12:30, HWB FKMLT
TBD
Hudson lab
TBD
Panne lab
Fri, 14. Jul. 2023
11:30, HWB FKMLT
TBD
Hopkinson lab
Fri, 21. Jul. 2023
12:30, HWB FKMLT
Megan Coulson
Naushin Hindul
Tanaka lab

MCB/LISCB Research-in-Progress Seminars 2021-22

Fri, 01. Oct. 2021
12:30, HWB FKMLT
Robert Turnbull
Schwabe lab
HDACs – Complex Specific Control of Gene Expression
Fri, 15. Oct. 2021
12:30, HWB FKMLT
Oksana Gonchar
Schwabe lab
Studying functions of histone deacetylase complexes- implications for therapeutic intervention
Jake Ward
Doveston lab
Characterisation of the 14-3-3/MDM2 protein-protein interaction
Fri, 22. Oct. 2021
12:30, HWB FKMLT
Ahmad Alshehri
Cowley lab
Investigating the physiological roles of HDAC1/2 in the embryonic stem cell acetylome
Hesna Kara
Dominguez lab
Are splicing factors cooperating or competing for alternative splicing regulation? A structural analysis of Bcl-x and SMN2 splicing.
Fri, 29. Oct. 2021
12:30, HWB FKMLT
Gareth Hall
Carr lab
Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease
Joshua Northcote-Smith
Suntharalingam lab
Breast Cancer Stem Cell Active Copper(II) Complexes with Salicylaldehyde and Polypyridyl Ligands
Fri, 05. Nov. 2021
12:30, HWB FKMLT
Vicki Emms
Hopkinson lab
“Profiling the effect of formaldehyde during gemcitabine chemotherapy”
Kellie Lucken
Fry lab
Investigating the role of EML4-ALK fusion proteins in mitotic progression of non-small cell lung cancer
Fri, 12. Nov. 2021
12:30, HWB FKMLT
Carlos Bueno Alejo
Hudson lab
HOW DO RNA-BINDING PROTEINS CONTROL SPLICE SITE SELECTION?: Single molecule tools
Christine Prosser
Carr lab
Antibody Assisted Drug Discovery (A2D2): Using Antibodies to Guide Small Molecule Research
Fri, 19. Nov. 2021
12:30, HWB FKMLT
Albati Amal Abdulah M
Macip lab
The role of BTK inhibition in amelioration of ageing and ageing related diseases in heart
Mishal Tariq
Tanaka lab
Structural Insight into Mode of Activation of Small G-Protein GEF
Fri, 26. Nov. 2021
12:30, HWB FKMLT
Neil Bate
Brindle lab
Inara Liepina
Dominguez lab
Functional investigation of the role of Cdk1 mediated phosphorylation of Sam68
Fri, 03. Dec. 2021
12:30, HWB FKMLT
Saba Imanzadeh
Mitcheson lab
"Investigating and understanding the gating mechanisms of KV1.1 channels" (TBC)
Fri, 14. Jan. 2022
12:30, HWB FKMLT
Megan Broderick
Cowley lab
“Investigating the role of Lysine Specific Demethylase 1 (LSD1) in embryonic development”
Lorna Waters
Carr lab
Using NMR to Characterise Protein-Drug Interactions (and Attempting to make Labelled Proteins in Insect Cells)
Fri, 21. Jan. 2022
12:30, HWB FKMLT
Ziad Ibrahim
Panne lab
Structural insights into large-scale genome compartmentalisation and dysregulation in disease
Sumera Tubasum
Eperon lab
Alternative fluorescent tags to visualize single-molecule colocalization
Fri, 28. Jan. 2022
12:30, HWB FKMLT
Kerry Blair
De Biasio lab
Complexes involved in Okazaki fragment maturation
Josh Smalley
Hodgkinson lab
Design and Synthesis of Novel PROTACs for Targeted Degradation of Class I HDACs in Corepressor Complexes
Fri, 04. Feb. 2022
12:30, HWB FKMLT
Ginevra Passeri
Suntharalingam lab
Biodegradable polymeric nanoparticles for the delivery of anti-cancer stem cell agents
Santosh Upadhyay 
Dominguez lab
Structural basis of interaction between NXF1 and SRSF1
Fri, 11. Feb. 2022
12:30, HWB FKMLT
Taha Shahid
De Biasio lab
Some new cryo-EM methods as applied to complexes involved in DNA replication
Siyu Wang
Schwabe lab
Merely MIER ? : Investigations into the MIER1 co-repressor complex
Fri, 18. Feb. 2022
12:30, HWB FKMLT
Sara Chothia
Hopkinson lab
Friend or Foe? The Complex Biochemistry of Formaldehyde
Andrey Revyakin
Revyakin lab
"New technologies for single-molecule imaging of complex biochemistry"
Fri, 25. Feb. 2022
12:30, HWB FKMLT
Neil Bate
Brindle lab
Can COVID-19 infect rats?
Bailey Luke T.
Schalch lab
The regulation of the H2B E3 ligase complex in the promotion of euchromatic domains
Fri, 04. Mar. 2022
12:30, HWB FKMLT
Nick Fowler
Vuister lab
NMR structure calculation post AlphaFold2. Why bother?
Fri, 11. Mar. 2022
12:30, HWB FKMLT
Alisha Mohindra
Doveston lab
Developing a Ligand Screening Platform to Discover Molecular Glues
Alexandra Rusu
Schalch lab
Investigating the secondary structure of the chromatin fibre
Fri, 18. Mar. 2022
12:30, HWB FKMLT
Hannah Smith
Macip lab
Characterising Markers of Senescence and Their Therapeutic Potential
Panayiota Stylianou
Gooptu lab
Molecular and cell studies of alpha1-antitrypsin misfolding and polymerisation
Fri, 25. Mar. 2022
12:30, HWB FKMLT
Tara Kang-Pettinger
Carr lab
"Antibody Assisted Drug Discovery"
Idir Malki
Dominguez lab
NMR investigation of the post-translational modifications of the oncogenic splicing factor Sam68.
Fri, 01. Apr. 2022
12:30, HWB FKMLT
Ed Brooksbank
Vuister lab
Louise Fairall
Schwabe lab
Interaction of the MiDAC histone deacetylase complex with chromatin
Fri, 08. Apr. 2022
12:30, HWB FKMLT
Sam Lee
Cowley lab
Investigating the roles of Sin3a in mouse embryonic stem cells
Fri, 29. Apr. 2022
12:30, HWB FKMLT
Fares Al Mansour
Macip lab
BTK inhibition reduces age-associated changes in mouse skin
Rory Cunnison
Revyakin lab
"Real-time single molecule visualization of human mitochondrial transcription dynamics"
Fri, 06. May. 2022
12:30, HWB FKMLT
Natasha Bulman
Hopkinson lab
“Developing a chemical toolkit to modulate cellular formaldehyde”
Amrita Patel
Panne lab
"Structural insights into the Cohesin complex and its role in chromosome biology"
Fri, 13. May. 2022
12:30, HWB FKMLT
Vasileios Paschalis
Eperon lab
Filling in the pieces in the splicing jigsaw

MCB/LISCB Research-in-Progress Meetings 2020-21

Fri, 25. Sep. 2020
13:30, online
Reserved for PhD Symposium
No Seminar
MCB/LISCB PhD symposium
Fri, 02. Oct. 2020
14:30, online
Chinar Pathak
Moody lab
Heme Peroxidases - Now and Then through Structural Viewpoint
Fri, 09. Oct. 2020
13:30, online
Grace Adams
Cowley lab
Understanding the role of Sin3A in mouse embryonic stem cells
Fri, 16. Oct. 2020
13:30, online
Marta Poblocka
Macip lab
Fri, 23. Oct. 2020
13:30, online
Shijie Cui
Eperon lab
Fri, 30. Oct. 2020
12:30, online
Ziad Ibrahim
Panne lab
Fri, 06. Nov. 2020
12:30, online
Leanne Blount
Hudson lab
Fri, 13. Nov. 2020
12:30, online
Alice Haworth
Shackleton lab
Fri, 20. Nov. 2020
12:30, online
Saeed Alghamdi
Cowley lab
Fri, 27. Nov. 2020
12:30, online
Jasmine Cross
Hodgkinson lab
Fri, 04. Dec. 2020
12:30, online
Donovan Lim
Cowley lab
Fri, 11. Dec. 2020
12:30, online
Daniel Bowden
Gyory lab
Fri, 18. Dec. 2020
12:30, online
Marta Poblocka
Macip lab
Fri, 08. Jan. 2021
12:30, online
Wafaa Al-Gburi
Willets lab
Fri, 15. Jan. 2021
12:30, online
Hesna Kara
Dominguez lab
Are splicing factors cooperating or competing for alternative splicing regulation? A structural analysis of Bcl-x and SMN2 splicing.”
Lorna Waters
Carr lab
“Understanding the Interaction of Interleukin-17 Dimers with their Receptors: From Interesting Observations in NMR Spectra to Understanding the Affect of Structural Changes on Receptor Binding”
Fri, 22. Jan. 2021
12:30, online
Louise Fairall
Schwabe lab
Towards an understanding of the interaction of Histone Deacetylase complexes with chromatin
Bailey Luke T.
Schalch lab
The regulation of the H2B E3 ligase complex in the promotion of euchromatic domains
Fri, 29. Jan. 2021
12:30, online
Marta Falcicchio
Doveston lab
Towards Covalent Approaches to Stabilise the 14-3-3 – p53 Protein-Protein Interaction as a Therapeutic Modality in Cancer”
Alice Johnson
Suntharalingam lab
"Macrocyclic Copper and Silver Complexes as Anti-Cancer Stem Cell Agents"
Fri, 05. Feb. 2021
12:30, online
Feletto Leonardo
Panne lab
Structural insights into 3D genome folding and expression
Eliza Ploskon
Vuister lab
Fri, 12. Feb. 2021
12:30, online
Rafael Del Villar Guerra
Dominguez lab
Biophysical and structural investigation of the role of GQC-05 in the alternative splicing of Bcl-X
Fri, 19. Feb. 2021
14:30, online
Alert, time change!
Luca Mureddu
Vuister lab
Development of new computational methods for fragment-based drug discovery by NMR.
Victoria Smith
Dyer lab
Mechanisms of acquired resistance to BH3 mimetics in diffuse large B-cell lymphoma (DLBCL)
Fri, 26. Feb. 2021
12:30, online
Ahmad Alshehri
Cowley lab
Investigating the physiological roles of HDAC1/2 in the embryonic stem cell acetylome
Fri, 05. Mar. 2021
12:30, online
Inara Liepina
Dominguez lab
"Investigating the effects of Serine/Threonine phosphorylation on Sam68 function"
Fri, 12. Mar. 2021
12:30, online
Natasha Bulman
Hopkinson lab
"Developing a chemical toolkit for the modulation of cellular formaldehyde"
Idir Malki
Dominguez lab
NMR investigation of the post-translational modifications of the oncogenic splicing factor Sam68
Fri, 19. Mar. 2021
12:30, online
Tara Kang-Pettinger
Carr lab
“Antibody Assisted Drug Discovery”
Fri, 26. Mar. 2021
12:30, online
Gareth Hall
Carr lab
Allosteric Activation of MALT1 by its Ubiquitin-Binding Ig3 Domain
Claudia Lancey
De Biasio lab
Cryo-EM analysis of human DNA polymerase complexes
Fri, 16. Apr. 2021
12:30, online
Amrita Patel
Panne lab
" Structural insights into the Cohesin complex and its role in chromosome biology"
Chitra Seewooruthun
Carr lab
Fri, 23. Apr. 2021
12:30, online
Sandrine Jayne
Dyer lab
CRLF2 as a novel therapeutic target for BCP-ALL and other malignancies
Hannah Smith
Macip lab
Fri, 30. Apr. 2021
12:30, online
Eman Alshehri
Patel lab
Analysis of the role of Cdk1/Cyclin B and Bax Interaction during Mitotic Checkpoint-Induced Apoptosis
Kayleigh Walker
Carr lab
"A2D2: from VHHs to small molecules"
Fri, 07. May. 2021
12:30, online
Eliza Ploskon
Vuister lab
“NMR-based biomolecular structure determination. Why is it still so difficult to do?”
Helena Wright
Carr lab
Fri, 14. May. 2021
12:30, online
Roberta Baravalle
Carr lab
Alexandra Rusu
Schalch lab
Investigating the role of chromatin fibre structure in genome function
Fri, 21. May. 2021
12:30, online
Vasileios Paschalis
Eperon lab
How do RNA-binding proteins control splice site selection?
Santosh Upadhyay 
Dominguez lab
Structural investigation on the interaction between SRSF1 and NXF1
Fri, 28. May. 2021
12:30, online
Sudipta Ghosh
Eperon lab
Mechanistic studies of a small-molecule modulator of BCL-X splicing
Sarah Northall
Schalch lab
Structural investigation on the interaction between SRSF1 and NXF1
Fri, 04. Jun. 2021
12:30, online
Daniel Burschowsky
Carr lab
Vicki Emms
Hopkinson lab
Fri, 11. Jun. 2021
12:30, online
Vicky Higman
Vuister lab
Fri, 18. Jun. 2021
12:30, online
Richard Cowan
Carr lab
Deep mining of early patient responses to COVID-19 – identification of cross-reactive SARS-CoV2 neutralizing antibodies
Siyu Wang
Schwabe lab
Fri, 25. Jun. 2021
12:30, online
Beatriz Romartinez
Schwabe lab
Panayiota Stylianou
Gooptu lab
Fri, 02. Jul. 2021
12:30, online
TJ Ragan
LISCB lab
Getting the most out of your data
Sumera Tubasum
Eperon lab
Colocalization-imaging approach to visualize the binding of splicing factors to pre-mRNA of prototype SMN2

MCB/LISCB Research-in-Progress Meetings 2019-20

Fri, 18. Oct. 2019
12:30, HWB FKMLT
Sarah Northall
Schalch lab
HelQ and CtIP: the tip of the iceberg of DNA repair
Santosh Upadhyay 
Dominguez lab
Molecular details to understand specific nucleic acid recognition sites by RNA binding proteins
Fri, 25. Oct. 2019
12:30, GDC LT2
Louise Fairall
Schwabe lab
Architecture of the MiDAC histone deacetylase complex
Amrita Patel
Panne lab
Structural and biochemical characterization of RING E3 mediated ubiquitination
Fri, 01. Nov. 2019
12:30, HWB FKMLT
Roberta Baravalle
Carr lab
Antibody-Assisted Drug Discovery (A2D2)
Alessandro Stirpe
Schalch lab
Histone H3K14 ubiquitination promotes heterochromatin formation
Fri, 08. Nov. 2019
12:30, HWB FKMLT
Mohammed Bhogadia
Dominguez lab
Molecular mechanism and interaction of GQC-05 on Bcl-x RNA
Chris Millard
Schwabe lab
Exploring the stoichiometry of the NuRD histone deacetylase complex
Fri, 15. Nov. 2019
12:30, HWB FKMLT
Sudipta Ghosh
Eperon lab
Splice switch leads to cell death: Role of a splicing modulator, GQC-05
James Norris
Hodgkinson lab
Design and Execution of a Dual Peptide Probe for LHC complex
Fri, 22. Nov. 2019
12:30, HWB FKMLT
Daniel Burschowsky
Carr lab
Structures of therapeutic antibodies explain arginase 2 activity modulation and reversal of immunosuppression
Anastasios Stavrou
Evans lab
Modeling and biochemical experiments on P2X proteins: Revealing new possible conformations?
Fri, 06. Dec. 2019
12:30, HWB FKMLT
Lia Hafiyani
Fry lab
Investigating the mechanisms of interaction between EMLs and NEKs in microtubule dynamic regulation
Gábor Tax
Roversi lab
Rescue of secretion of rare disease-associated misfolded glycoproteins: Panacea or Pandora's Box?
Fri, 10. Jan. 2020
12:30, HWB FKMLT
No Seminar
RSC Chemical Biology Meeting
Fri, 17. Jan. 2020
12:30, HWB FKMLT
Richard Cowan
Carr lab
Allosteric Regulation of PlexinB1 Revealed by Inhibitory Antibodies
Vicki Emms
Hopkinson lab
Profiling the effect of the metabolite formaldehyde during gemcitabine chemotherapy
Fri, 24. Jan. 2020
12:30, HWB FKMLT
Oksana Gonchar
Schwabe lab
Real-time single molecule studies of RNA Pol II transcription initiation.
Vicky Higman
Vuister lab
Developing data analysis software fit for 21st century users.
Fri, 31. Jan. 2020
12:30, HWB FKMLT
No Seminar
Departmental staff meeting
Fri, 07. Feb. 2020
12:30, HWB FKMLT
David English
Cowley lab
Investigating the role of HDAC1 in early embryonic development.
Helena Wright
Carr lab
Antibody Assisted Drug Discovery
Fri, 14. Feb. 2020
13:30, HWB FKMLT
late start due to pymol tutorials
Jacqueline Kalms
Carr lab
Antibody-Assisted Structure-Based Drug Discovery: Receptor type Protein tyrosine phosphatase (PTP)
Vasileios Paschalis
Eperon lab
HDACs and DNA repair: SMRT and MutSβ complexes
Fri, 21. Feb. 2020
12:30, HWB FKMLT
Alistair Fryatt
Mitcheson lab
Studying cardiac ventricular myocytes in aging and disease: A tale of two hearts
Matthew Powell-Grabaskey
Carr lab
Antibody Assisted Drug Discovery: Antibody Assisted Investigations Into Allosteric Regulation of Sclerostin
Fri, 28. Feb. 2020
12:30, HWB FKMLT
Robert Turnbull
Schwabe lab
MiDAC: Essential, Unique, Misaligned. Studying the role of a novel HDAC complex
Fri, 06. Mar. 2020
12:30, HWB FKMLT
Hatice Esenkaya
Dominguez lab
Investigating the effects of G-quadruplex stabilising ligand GQC-05 on alternative splicing of Mcl-1 pre-mRNA
Laura Jones
Wallis lab
Molecular analysis of complement activation via the C1 complex
Fri, 13. Mar. 2020
12:30, HWB FKMLT
Neil Bate
Brindle lab
Using Directed Evolution to Elucidate Protein-Protein Interactions
Ed Brown
Schwabe lab
Structure and function of the RERE Complex: an atypical class 1 HDAC complex
Fri, 20. Mar. 2020
12:30, HWB FKMLT
Alvaro Garcia
Piletsky lab
Smart polymer nano-particles for medical diagnosis, customise robust sensors
Panayiota Stylianou
Gooptu lab
Insights in “Gal-3 fibrosome” organisation and dynamics using cell biology and light microscopy
Fri, 27. Mar. 2020
12:30, HWB FKMLT
Shijie Cui
Eperon lab
Alice Haworth
Shackleton lab
Fri, 03. Apr. 2020
12:30, HWB FKMLT
Marta Poblocka
Macip lab
Panayiota Stylianou
Gooptu lab
Fri, 17. Apr. 2020
12:30, HWB FKMLT
Rafael Del Villar Guerra
Dominguez lab
Emily Richardson
Fry lab
Fri, 24. Apr. 2020
12:30, HWB FKMLT
Shijie Cui
Eperon lab
Alice Haworth
Shackleton lab
Fri, 01. May. 2020
12:30, HWB FKMLT
Sandrine Jayne
Dyer lab
Chinar Pathak
Moody lab
Fri, 15. May. 2020
12:30, HWB FKMLT
Saeed Alghamdi
Cowley lab
Beatriz Romartinez
Schwabe lab
Mike Whitcombe
Piletsky lab
Fri, 22. May. 2020
12:30, HWB FKMLT
Atiqah Sulaiman
Patel lab
Fri, 29. May. 2020
12:30, HWB FKMLT
Donovan Lim
Cowley lab
Idir Malki
Dominguez lab
Fri, 05. Jun. 2020
12:30, HWB FKMLT
Wafaa Al-Gburi
Willets lab
Simon Fung
Hudson lab
Gareth Hall
Carr lab
Fri, 12. Jun. 2020
12:30, HWB FKMLT
Leanne Blount
Hudson lab
Chitra Seewooruthun
Carr lab
Fri, 19. Jun. 2020
12:30, HWB FKMLT
Victoria Smith
Dyer lab
Lorna Waters
Carr lab
Fri, 26. Jun. 2020
12:30, HWB FKMLT
Ross Jackson
Dyer lab
Fri, 03. Jul. 2020
12:30, HWB FKMLT
Grace Adams
Cowley lab
Kayleigh Walker
Carr lab
Fri, 10. Jul. 2020
12:30, HWB FKMLT
Daniel Bowden
Gyory lab