MCB/LISCB Research-in-Progress Seminars 2023-24
Fri, 07. Oct. 2022
12:30, HWB FKMLT
Oksana Gonchar
Schwabe lab
Studying functions of histone deacetylase complexes
Structural and molecular insights into Cohesin and its release factor WAPL
Fri, 14. Oct. 2022
00:30, HWB FKMLT
Richard J. Hopkinson
Hopkinson lab
Defining the enigmatic biology of aldehydes
Fri, 04. Nov. 2022
12:30, HWB FKMLT
Carlos Bueno Alejo
Hudson lab
Fluorous effect in single molecule microscopy
Dissecting the regulatory mechanisms governing the histone 3 lysine 9 methyltransferase Clr4
Fri, 11. Nov. 2022
12:30, HWB FKMLT
Robert Liddington
Moody lab
PurC as a potential target for novel therapeutics to treat multi-drug resistant tuberculosis.
Fri, 18. Nov. 2022
12:30, HWB FKMLT
Predicting Antibody:Target interfaces and novel protein:protein interactions with Alphafold
Beatriz Romartinez
Schwabe lab
Structural insight into the cholesterol transport and lipid metabolism
Fri, 25. Nov. 2022
12:30, HWB FKMLT
‘Investigating the role of HDAC1 containing corepressor complexes’
Fri, 02. Dec. 2022
12:30, HWB FKMLT
Structural investigation of cohesin cycle
Investigations into the MIER1 co-repressor complex
Fri, 09. Dec. 2022
12:30, HWB FKMLT
Fri, 13. Jan. 2023
12:30, HWB FKMLT
FluoroTensor - A Python Package for Single Molecule TIRF Analysis
Fri, 20. Jan. 2023
12:30, HWB FKMLT
Beth Thurairajah
Doveston lab
Developing a Toolbox to Study Molecular Glue Kinetics
Robert Turnbull
Schwabe lab
“Integrating structural and multi-omics approaches to study HDAC complexes”.
Fri, 27. Jan. 2023
12:30, HWB FKMLT
Charlie Hitchman
Gooptu lab
Structural characterisation of EDEM:PDI, the glycoprotein folding ERAD checkpoint
Fri, 03. Feb. 2023
12:30, HWB FKMLT
Developing Proteolysis Targeting Chimeras to Individual Class-I HDAC Complexes
"The Role of BMX in Cell Fate Decisions"
Fri, 10. Feb. 2023
12:30, HWB FKMLT
Louise Fairall
Schwabe lab
Interaction of the MiDAC histone deacetylase complex with chromatin
Fri, 17. Feb. 2023
12:30, HWB FKMLT
Mechanistic Understanding of cohesin complex and its accessory ligands role in chromosome biology
Fri, 03. Mar. 2023
12:30, HWB FKMLT
Wiktoria Pytel
Hodgkinson lab
Chemical probes to study class I histone deacetylase complexes
Fri, 10. Mar. 2023
12:30, HWB FKMLT
Probing HDAC substrate specificity with chemical tools
Fri, 17. Mar. 2023
12:30, HWB FKMLT
“Deciphering the biochemistry of aldehydes using small molecule tools”
Fri, 24. Mar. 2023
12:30, HWB FKMLT
Khondoker Akram
Gooptu lab
What’s a cell and tissue biologist doing at LISCB?
Fri, 21. Apr. 2023
11:30, HWB FKMLT
“Investigating NuRD Complex structure and its interaction with chromatin.”
Fri, 28. Apr. 2023
12:30, HWB FKMLT
Iridium complexes for imaging formaldehyde
In situ spectroscopy of metalloenzymes
Fri, 05. May. 2023
11:30, HWB FKMLT
India-May Baker
Cowley lab
A Multiomics Approach to Elucidating the Specific Genomic Targets Regulated by Histone Deacetylase 3 (HDAC3)
Fri, 12. May. 2023
12:30, HWB FKMLT
Is the cross-heme peroxidase model universally applicable?
Structural characterisation of Bach1 CP motifs with heme
Fri, 19. May. 2023
11:30, HWB FKMLT
BMX regulation by PTPN21 determines sensitivity to BAK-dependent apoptotic cell death
Fri, 09. Jun. 2023
12:30, HWB FKMLT
Pleiotropic impact of endogenously expressed KRAS.G12V oncogenic mutation in near-diploid human cell line hTERT RPE-1
“Studies of Glofitamab, a CD3xCD20 bispecific antibody, in B cell malignancies”
Fri, 16. Jun. 2023
11:30, HWB FKMLT
Kristupas Sirvydus
Schwabe lab
Fri, 30. Jun. 2023
11:30, HWB FKMLT
Fri, 07. Jul. 2023
12:30, HWB FKMLT
MCB/LISCB Research-in-Progress Seminars 2021-22
Fri, 01. Oct. 2021
12:30, HWB FKMLT
Robert Turnbull
Schwabe lab
HDACs – Complex Specific Control of Gene Expression
Fri, 15. Oct. 2021
12:30, HWB FKMLT
Oksana Gonchar
Schwabe lab
Studying functions of histone deacetylase complexes- implications for therapeutic intervention
Characterisation of the 14-3-3/MDM2 protein-protein interaction
Fri, 22. Oct. 2021
12:30, HWB FKMLT
Investigating the physiological roles of HDAC1/2 in the embryonic stem cell acetylome
Are splicing factors cooperating or competing for alternative splicing regulation? A structural analysis of Bcl-x and SMN2 splicing.
Fri, 29. Oct. 2021
12:30, HWB FKMLT
Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease
Joshua Northcote-Smith
Suntharalingam lab
Breast Cancer Stem Cell Active Copper(II) Complexes with Salicylaldehyde and Polypyridyl Ligands
Fri, 05. Nov. 2021
12:30, HWB FKMLT
“Profiling the effect of formaldehyde during gemcitabine chemotherapy”
Investigating the role of EML4-ALK fusion proteins in mitotic progression of non-small cell lung cancer
Fri, 12. Nov. 2021
12:30, HWB FKMLT
Carlos Bueno Alejo
Hudson lab
HOW DO RNA-BINDING PROTEINS CONTROL SPLICE SITE SELECTION?: Single molecule tools
Christine Prosser
Carr lab
Antibody Assisted Drug Discovery (A2D2): Using Antibodies to Guide Small Molecule Research
Fri, 19. Nov. 2021
12:30, HWB FKMLT
Albati Amal Abdulah M
Macip lab
The role of BTK inhibition in amelioration of ageing and ageing related diseases in heart
Structural Insight into Mode of Activation of Small G-Protein GEF
Fri, 26. Nov. 2021
12:30, HWB FKMLT
Inara Liepina
Dominguez lab
Functional investigation of the role of Cdk1 mediated phosphorylation of Sam68
Fri, 03. Dec. 2021
12:30, HWB FKMLT
Saba Imanzadeh
Mitcheson lab
"Investigating and understanding the gating mechanisms of KV1.1 channels" (TBC)
Fri, 14. Jan. 2022
12:30, HWB FKMLT
Megan Broderick
Cowley lab
“Investigating the role of Lysine Specific Demethylase 1 (LSD1) in embryonic development”
Using NMR to Characterise Protein-Drug Interactions (and Attempting to make Labelled Proteins in Insect Cells)
Fri, 21. Jan. 2022
12:30, HWB FKMLT
Structural insights into large-scale genome compartmentalisation and dysregulation in disease
Alternative fluorescent tags to visualize single-molecule colocalization
Fri, 28. Jan. 2022
12:30, HWB FKMLT
Complexes involved in Okazaki fragment maturation
Josh Smalley
Hodgkinson lab
Design and Synthesis of Novel PROTACs for Targeted Degradation of Class I HDACs in Corepressor Complexes
Fri, 04. Feb. 2022
12:30, HWB FKMLT
Ginevra Passeri
Suntharalingam lab
Biodegradable polymeric nanoparticles for the delivery of anti-cancer stem cell agents
Santosh Upadhyay
Dominguez lab
Structural basis of interaction between NXF1 and SRSF1
Fri, 11. Feb. 2022
12:30, HWB FKMLT
Some new cryo-EM methods as applied to complexes involved in DNA replication
Merely MIER ? : Investigations into the MIER1 co-repressor complex
Fri, 18. Feb. 2022
12:30, HWB FKMLT
Sara Chothia
Hopkinson lab
Friend or Foe? The Complex Biochemistry of Formaldehyde
Andrey Revyakin
Revyakin lab
"New technologies for single-molecule imaging of complex biochemistry"
Fri, 25. Feb. 2022
12:30, HWB FKMLT
Can COVID-19 infect rats?
Bailey Luke T.
Schalch lab
The regulation of the H2B E3 ligase complex in the promotion of euchromatic domains
Fri, 04. Mar. 2022
12:30, HWB FKMLT
NMR structure calculation post AlphaFold2. Why bother?
Fri, 11. Mar. 2022
12:30, HWB FKMLT
Alisha Mohindra
Doveston lab
Developing a Ligand Screening Platform to Discover Molecular Glues
Alexandra Rusu
Schalch lab
Investigating the secondary structure of the chromatin fibre
Fri, 18. Mar. 2022
12:30, HWB FKMLT
Characterising Markers of Senescence and Their Therapeutic Potential
Panayiota Stylianou
Gooptu lab
Molecular and cell studies of alpha1-antitrypsin misfolding and polymerisation
Fri, 25. Mar. 2022
12:30, HWB FKMLT
Tara Kang-Pettinger
Carr lab
"Antibody Assisted Drug Discovery"
NMR investigation of the post-translational modifications of the oncogenic splicing factor Sam68.
Fri, 01. Apr. 2022
12:30, HWB FKMLT
Louise Fairall
Schwabe lab
Interaction of the MiDAC histone deacetylase complex with chromatin
Fri, 08. Apr. 2022
12:30, HWB FKMLT
Investigating the roles of Sin3a in mouse embryonic stem cells
Fri, 29. Apr. 2022
12:30, HWB FKMLT
Fares Al Mansour
Macip lab
BTK inhibition reduces age-associated changes in mouse skin
Rory Cunnison
Revyakin lab
"Real-time single molecule visualization of human mitochondrial transcription dynamics"
Fri, 06. May. 2022
12:30, HWB FKMLT
Natasha Bulman
Hopkinson lab
“Developing a chemical toolkit to modulate cellular formaldehyde”
"Structural insights into the Cohesin complex and its role in chromosome biology"
Fri, 13. May. 2022
12:30, HWB FKMLT
Vasileios Paschalis
Eperon lab
Filling in the pieces in the splicing jigsaw
MCB/LISCB Research-in-Progress Meetings 2020-21
Fri, 25. Sep. 2020
13:30, online
Fri, 02. Oct. 2020
14:30, online
Heme Peroxidases - Now and Then through Structural Viewpoint
Fri, 09. Oct. 2020
13:30, online
Understanding the role of Sin3A in mouse embryonic stem cells
Fri, 16. Oct. 2020
13:30, online
Fri, 23. Oct. 2020
13:30, online
Fri, 30. Oct. 2020
12:30, online
Fri, 06. Nov. 2020
12:30, online
Fri, 13. Nov. 2020
12:30, online
Alice Haworth
Shackleton lab
Fri, 20. Nov. 2020
12:30, online
Fri, 27. Nov. 2020
12:30, online
Jasmine Cross
Hodgkinson lab
Fri, 04. Dec. 2020
12:30, online
Fri, 11. Dec. 2020
12:30, online
Fri, 18. Dec. 2020
12:30, online
Fri, 08. Jan. 2021
12:30, online
Wafaa Al-Gburi
Willets lab
Fri, 15. Jan. 2021
12:30, online
Are splicing factors cooperating or competing for alternative splicing regulation? A structural analysis of Bcl-x and SMN2 splicing.”
“Understanding the Interaction of Interleukin-17 Dimers with their Receptors: From Interesting Observations in NMR Spectra to Understanding the Affect of Structural Changes on Receptor Binding”
Fri, 22. Jan. 2021
12:30, online
Louise Fairall
Schwabe lab
Towards an understanding of the interaction of Histone Deacetylase complexes with chromatin
Bailey Luke T.
Schalch lab
The regulation of the H2B E3 ligase complex in the promotion of euchromatic domains
Fri, 29. Jan. 2021
12:30, online
Marta Falcicchio
Doveston lab
Towards Covalent Approaches to Stabilise the 14-3-3 – p53 Protein-Protein Interaction as a Therapeutic Modality in Cancer”
Alice Johnson
Suntharalingam lab
"Macrocyclic Copper and Silver Complexes as Anti-Cancer Stem Cell Agents"
Fri, 05. Feb. 2021
12:30, online
Feletto Leonardo
Panne lab
Structural insights into 3D genome folding and expression
Fri, 12. Feb. 2021
12:30, online
Rafael Del Villar Guerra
Dominguez lab
Biophysical and structural investigation of the role of GQC-05 in the alternative splicing of Bcl-X
Fri, 19. Feb. 2021
14:30, online
Development of new computational methods for fragment-based drug discovery by NMR.
Mechanisms of acquired resistance to BH3 mimetics in diffuse large B-cell lymphoma (DLBCL)
Fri, 26. Feb. 2021
12:30, online
Investigating the physiological roles of HDAC1/2 in the embryonic stem cell acetylome
Fri, 05. Mar. 2021
12:30, online
Inara Liepina
Dominguez lab
"Investigating the effects of Serine/Threonine phosphorylation on Sam68 function"
Fri, 12. Mar. 2021
12:30, online
Natasha Bulman
Hopkinson lab
"Developing a chemical toolkit for the modulation of cellular formaldehyde"
NMR investigation of the post-translational modifications of the oncogenic splicing factor Sam68
Fri, 19. Mar. 2021
12:30, online
Tara Kang-Pettinger
Carr lab
“Antibody Assisted Drug Discovery”
Fri, 26. Mar. 2021
12:30, online
Allosteric Activation of MALT1 by its Ubiquitin-Binding Ig3 Domain
Claudia Lancey
De Biasio lab
Cryo-EM analysis of human DNA polymerase complexes
Fri, 16. Apr. 2021
12:30, online
" Structural insights into the Cohesin complex and its role in chromosome biology"
Chitra Seewooruthun
Carr lab
Fri, 23. Apr. 2021
12:30, online
CRLF2 as a novel therapeutic target for BCP-ALL and other malignancies
Fri, 30. Apr. 2021
12:30, online
Analysis of the role of Cdk1/Cyclin B and Bax Interaction during Mitotic Checkpoint-Induced Apoptosis
"A2D2: from VHHs to small molecules"
Fri, 07. May. 2021
12:30, online
“NMR-based biomolecular structure determination. Why is it still so difficult to do?”
Fri, 14. May. 2021
12:30, online
Roberta Baravalle
Carr lab
Alexandra Rusu
Schalch lab
Investigating the role of chromatin fibre structure in genome function
Fri, 21. May. 2021
12:30, online
Vasileios Paschalis
Eperon lab
How do RNA-binding proteins control splice site selection?
Santosh Upadhyay
Dominguez lab
Structural investigation on the interaction between SRSF1 and NXF1
Fri, 28. May. 2021
12:30, online
Mechanistic studies of a small-molecule modulator of BCL-X splicing
Sarah Northall
Schalch lab
Structural investigation on the interaction between SRSF1 and NXF1
Fri, 04. Jun. 2021
12:30, online
Daniel Burschowsky
Carr lab
Fri, 11. Jun. 2021
12:30, online
Fri, 18. Jun. 2021
12:30, online
Deep mining of early patient responses to COVID-19 – identification of cross-reactive SARS-CoV2 neutralizing antibodies
Fri, 25. Jun. 2021
12:30, online
Beatriz Romartinez
Schwabe lab
Panayiota Stylianou
Gooptu lab
Fri, 02. Jul. 2021
12:30, online
Getting the most out of your data
Colocalization-imaging approach to visualize the binding of splicing factors to pre-mRNA of prototype SMN2
MCB/LISCB Research-in-Progress Meetings 2019-20
Fri, 18. Oct. 2019
12:30, HWB FKMLT
Sarah Northall
Schalch lab
HelQ and CtIP: the tip of the iceberg of DNA repair
Santosh Upadhyay
Dominguez lab
Molecular details to understand specific nucleic acid recognition sites by RNA binding proteins
Fri, 25. Oct. 2019
12:30, GDC LT2
Louise Fairall
Schwabe lab
Architecture of the MiDAC histone deacetylase complex
Structural and biochemical characterization of RING E3 mediated ubiquitination
Fri, 01. Nov. 2019
12:30, HWB FKMLT
Roberta Baravalle
Carr lab
Antibody-Assisted Drug Discovery (A2D2)
Alessandro Stirpe
Schalch lab
Histone H3K14 ubiquitination promotes heterochromatin formation
Fri, 08. Nov. 2019
12:30, HWB FKMLT
Mohammed Bhogadia
Dominguez lab
Molecular mechanism and interaction of GQC-05 on Bcl-x RNA
Exploring the stoichiometry of the NuRD histone deacetylase complex
Fri, 15. Nov. 2019
12:30, HWB FKMLT
Splice switch leads to cell death: Role of a splicing modulator, GQC-05
James Norris
Hodgkinson lab
Design and Execution of a Dual Peptide Probe for LHC complex
Fri, 22. Nov. 2019
12:30, HWB FKMLT
Daniel Burschowsky
Carr lab
Structures of therapeutic antibodies explain arginase 2 activity modulation and reversal of immunosuppression
Anastasios Stavrou
Evans lab
Modeling and biochemical experiments on P2X proteins: Revealing new possible conformations?
Fri, 06. Dec. 2019
12:30, HWB FKMLT
Investigating the mechanisms of interaction between EMLs and NEKs in microtubule dynamic regulation
Rescue of secretion of rare disease-associated misfolded glycoproteins: Panacea or Pandora's Box?
Fri, 10. Jan. 2020
12:30, HWB FKMLT
RSC Chemical Biology Meeting
Fri, 17. Jan. 2020
12:30, HWB FKMLT
Allosteric Regulation of PlexinB1 Revealed by Inhibitory Antibodies
Profiling the effect of the metabolite formaldehyde during gemcitabine chemotherapy
Fri, 24. Jan. 2020
12:30, HWB FKMLT
Oksana Gonchar
Schwabe lab
Real-time single molecule studies of RNA Pol II transcription initiation.
Developing data analysis software fit for 21st century users.
Fri, 31. Jan. 2020
12:30, HWB FKMLT
Departmental staff meeting
Fri, 07. Feb. 2020
12:30, HWB FKMLT
Investigating the role of HDAC1 in early embryonic development.
Antibody Assisted Drug Discovery
Fri, 14. Feb. 2020
13:30, HWB FKMLT
Antibody-Assisted Structure-Based Drug Discovery: Receptor type Protein tyrosine phosphatase (PTP)
Vasileios Paschalis
Eperon lab
HDACs and DNA repair: SMRT and MutSβ complexes
Fri, 21. Feb. 2020
12:30, HWB FKMLT
Alistair Fryatt
Mitcheson lab
Studying cardiac ventricular myocytes in aging and disease: A tale of two hearts
Matthew Powell-Grabaskey
Carr lab
Antibody Assisted Drug Discovery: Antibody Assisted Investigations Into Allosteric Regulation of Sclerostin
Fri, 28. Feb. 2020
12:30, HWB FKMLT
Robert Turnbull
Schwabe lab
MiDAC: Essential, Unique, Misaligned. Studying the role of a novel HDAC complex
Fri, 06. Mar. 2020
12:30, HWB FKMLT
Hatice Esenkaya
Dominguez lab
Investigating the effects of G-quadruplex stabilising ligand GQC-05 on alternative splicing of Mcl-1 pre-mRNA
Molecular analysis of complement activation via the C1 complex
Fri, 13. Mar. 2020
12:30, HWB FKMLT
Using Directed Evolution to Elucidate Protein-Protein Interactions
Structure and function of the RERE Complex: an atypical class 1 HDAC complex
Fri, 20. Mar. 2020
12:30, HWB FKMLT
Alvaro Garcia
Piletsky lab
Smart polymer nano-particles for medical diagnosis, customise robust sensors
Panayiota Stylianou
Gooptu lab
Insights in “Gal-3 fibrosome” organisation and dynamics using cell biology and light microscopy
Fri, 27. Mar. 2020
12:30, HWB FKMLT
Alice Haworth
Shackleton lab
Fri, 03. Apr. 2020
12:30, HWB FKMLT
Panayiota Stylianou
Gooptu lab
Fri, 17. Apr. 2020
12:30, HWB FKMLT
Rafael Del Villar Guerra
Dominguez lab
Fri, 24. Apr. 2020
12:30, HWB FKMLT
Alice Haworth
Shackleton lab
Fri, 01. May. 2020
12:30, HWB FKMLT
Fri, 15. May. 2020
12:30, HWB FKMLT
Beatriz Romartinez
Schwabe lab
Mike Whitcombe
Piletsky lab
Fri, 22. May. 2020
12:30, HWB FKMLT
Fri, 29. May. 2020
12:30, HWB FKMLT
Fri, 05. Jun. 2020
12:30, HWB FKMLT
Wafaa Al-Gburi
Willets lab
Fri, 12. Jun. 2020
12:30, HWB FKMLT
Chitra Seewooruthun
Carr lab
Fri, 19. Jun. 2020
12:30, HWB FKMLT
Fri, 26. Jun. 2020
12:30, HWB FKMLT
Fri, 03. Jul. 2020
12:30, HWB FKMLT
Fri, 10. Jul. 2020
12:30, HWB FKMLT